Mitochondrial maintenance & PGC-1alpha
نویسندگان
چکیده
PGC-1α is a transcription coactivator centrally involved in the regulation of energy balance and metabolism. A recent study in Cell Metabolism adds another role for Pgc-1α, namely gene regulation in mitochondrial maintenance and metabolic homeostasis. The latest findings indicate significant increases in levels of DNA methylation within the promoter region of the Pgc-1α gene within human skeletal muscles from subjects with impaired glucose tolerance or type 2 diabetes. The significance and implications of this discovery are discussed.
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